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RUP response to COVID-19 crisis

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JEM staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JEM staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

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Article

| July 31 2023

GATA2-regulated developmental trajectories

Kirby D. Johnson, Daniel J. Conn, Evgenia Shishkova, Koichi R. Katsumura, Peng Liu, Siqi Shen, Erik A. Ranheim, Sean G. Kraus, Weixin Wang, Katherine R. Calvo, Amy P. Hsu, Steven M. Holland, Joshua J. Coon, Sunduz Keles, Emery H. Bresnick

By elevating levels of the GATA2 transcription factor in hematopoietic progenitor cells, a transcriptional enhancer establishes multilineage differentiation potential. During embryogenesis, deleting the enhancer upregulates innate immune machinery and deconstructs multilineage potential to favor monocytic differentiation.

Article

| July 29 2023

The existence of a circulating CD8 + T RM precursor

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Following local inflammation, CD8+ T cells develop into tissue-resident memory T cells (TRM). Through combined lineage tracing and single-cell transcriptome analysis, the authors show that the circulating T cell pool harbors TRM precursors that commit to the TRM fate before tissue entry.

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Brief Definitive Report

| July 29 2023

Aberrant AKT activation drives ganglioneuroma

锐速破解版一键安装包 | 厘米天空:2021-4-7 · 大概2月伇的时候锐速宣布不再免费，原来宣传的永久免费20M也没了。一时间让广大vps爱好者陷入低谷，不过各路破解高手也是不断抛砖引玉，从开始的改MAC方法到后来的算lic方法，现在连一键安装包都出来了，算是比较成熟了吧。这里转载一个用的比较多的一键安装包，亲测可用，由91yun.org博 …

Sketch54 for mac汉化破解版_sketch_skssr_top的博客 ...:2021-4-29 · sketch mac 破解版中文设置 1.有小伙伴反馈了sketch mac 破解版安装完成后是英文版，这个怎么设置？请往下看。 2.打开安装好的sketch mac 破解版，如图，打开 plugins，选择 sketchl18n，点击 toggle l18n，完成后软件就是中文啦。 Sketch Mac 破解版软件

Brief Definitive Report

| July 28 2023

A defect in STING trafficking causes COPA syndrome

Zimu Deng, Zhenlu Chong, Christopher S. Law, Kojiro Mukai, Frances O. Ho, Tereza Martinu, Bradley J. Backes, Walter L. Eckalbar, Tomohiko Taguchi, Anthony K. Shum

A defect in COPI transport due to mutant COPA causes multimerization of STING on the Golgi and type I interferon–driven immune dysregulation in mice. Small-molecule inhibition of STING activation is a new molecular target for treating COPA syndrome.

Brief Definitive Report

| July 28 2023

Plasma p-tau isoforms’ utility for AD diagnosis

Nicolas R. Barthélemy, Kanta Horie, Chihiro Sato, Randall J. Bateman

萌娘学院中文破解版下载-萌娘学院(附攻略伍及福利)最新破解 ...:今天 · 萌娘学院破解版是一款非常有趣的二次元养成类的手游，萌娘学院破解版的游戏中采用精美的游戏画面伍及可爱生动的人物形象，日系风格的画风也会吸引更多的玩家。另外简单的游戏操作，亲密的互动玩法也会让玩家血脉喷张！宅男伊的福音哦！

| July 28 2023

COPA regulates interferon signaling through STING

Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A. Marsh, Carolina Uggenti, Gillian I. Rice, Vincent Bondet, Darragh Duffy, Jonny Hertzog, Jan Rehwinkel, Serge Amselem, Siham Boulisfane-El Khalifi, Mary Brennan, Edwin Carter, Lucienne Chatenoud, Stéphanie Chhun, Aurore Coulomb l’Hermine, Marine Depp, Marie Legendre, Karen J. Mackenzie, Jonathan Marey, Catherine McDougall, Kathryn J. McKenzie, Thierry Jo Molina, Bénédicte Neven, Luis Seabra, Caroline Thumerelle, Marie Wislez, Nadia Nathan, Nicolas Manel, Yanick J. Crow, Marie-Louise Frémond

Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis. Based on these results, three patients have been treated with interferon signaling (JAK1) inhibitors.

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Article

| July 27 2023

Proteome-wide profiling of HPV-specific T cell immunity

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Proteome-wide profiling of HPV-specific T cell immunity in oropharyngeal cancer (OPC) patients reveals broad and multiple antigen-specific reactivities directed to HPV-encoded proteins E1, E2, E4, E5 E6, E7, and L1. These observations provide novel insights for future development of cellular immunotherapies for HPV-associated OPC patients.

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Current Issue

Volume 217,

Issue 8,

August 3, 2023

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People & Ideas

| July 31 2023

Lessons of COVID-19: Virtual conferences

Stephanie Houston

Lessons of COVID-19: Virtual conferences

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Viewpoint

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Lessons in pandemic times

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Insights

| July 22 2023

Talin1 affects migration and TLR signaling in DCs

Björn E. Clausen

In dendritic cells, talin1 links integrin binding to efficient TLR downstream signaling through interaction with MyD88 and PIP5K.

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快连2.18.8

Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8⁺ T cells

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

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Neuroscience 2023

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